Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

Ovarian cancer histopathology

Several previous studies have identified an association between endometriosis and the development of ovarian carcinomas. This study aims to follow-up the prevalence of endometriosis and the histological features in ovarian cancer histopathology tumors. Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale Materials and method.

Ovarian tumours (benign and malignant) cauzele cancerului de plamani

The study group included 50 patients from ovarian cancer or endometriosis County Emergency Hospital of Galaţi diagnosed with different histological types of ovarian tumors of the surface epithelium during the period The cases were reviewed in order to highlight the presence of endometriosis and the ovarian cancer or endometriosis histopathological changes.

The average age of patients in the group with endometriosis associated with ovarian tumors was Ovarian cancer or endometriosis the seven cases of tumors associated with endometriosis, two presented areas with atypia, considered premalignant lesions.

Based on data obtained, we can conclude that endometriosis with atypia can be a precursor to the occurrence of type I ovarian carcinomas. Keywords endometriosis, ovarian cancer, atypical endometriosis, premalignant lesion Rezumat Introducere. Mai multe studii anterioare au identificat o asociere între ovarian cancer histopathology şi dezvoltarea carcinoamelor ovariene. Acest studiu urmăreşte prevalenţa endometriozei şi caracteristicile histologice în ovarian cancer histopathology ovariene.

Materiale şi metodă. În lotul de studiu au fost incluse 50 de paciente diagnosticate cu diferite tipuri histologice de tumori ovariene ale epiteliului de suprafaţă cancerul de col uterin amg perioada la Spitalul Judeţean de Urgenţă din Galaţi. Cazurile au fost reanalizate în vederea evidenţierii prezenţei endometriozei, precum şi a diferitelor modificări histopatologice ale acestora. Vârsta medie a pacientelor a fost ovarian cancer or endometriosis ani în lotul pacientelor care au prezentat endometrioză asociată şi 59,5±13,4 ani în lotul pacientelor ovarian cancer or endometriosis au prezentat doar tumori ovariene.

Din cele şapte cazuri de endometrioză, în două cazuri au fost evidenţiate zone cu atipii, considerate leziuni premaligne. Identificarea endometriozei cu atipii la cele două cazuri — unul diagnosticat cu carcinom cu celule clare, iar celălalt cu carcinom endometrial, ambele incluse în tipul I de cancer ovarian — demonstrează faptul că endometrioza cu atipii poate fi un precursor în apariţia carcinoamelor ovariene de tip I.

Endometriosis is a gynecological condition, being characterized from a histopathological point of view ovarian cancer histopathology the presence of glandular structures at the level of the endometrium and stroma in ectopic locations, such as ovary, ovarian cancer histopathology, bladder, Fallopian tube, ovary ovarian cancer or endometriosis the most common location 4,5.

The literature comprises multiple studies highlighting the link between the presence ovarian cancer or endometriosis endometriosis and its malignant transformation in the ovary, although ovarian cancer histopathology studies have not identified associations between these two 6,7. It is estimated that the risk of malignant transformation of endometriosis is comprised between 0.

Ovarian cancer or endometriosis

Recognizing the symptoms of endometrial cancer Endometriosis with atypia is described as a preneoplastic lesion and is considered an intermediate pathway for the development of ovarian carcinoma 3.

InSampson described for the first time the implications of endometriosis in neoplastic lesions by establishing several important criteria: the presence of endometriosis and the tumor in the same ovary, a similar histological pattern, the exclusion of the ovarian cancer histopathology of tumor metastasis from other locations 8.

InScott added one more criterion: highlighting the continuity between the benign and the malignant ovarian cancer or endometriosis 9.

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Atypia from endometriosis was proposed as a preneoplastic ovarian cancer or endometriosis between endometriosis and ovarian cancer, as it refers to two major histological ovarian cancer histopathology cytological atypia and architectural atypia known as hyperplasia Cytological atypia is highlighted in the epithelium of an endometrial cyst, while the hyperplasia resembles to the hyperplasia present in the endometrium simple or complex with or without atypia Materials and method The study comprises patients of the Emergency County Hospital of Galaţi diagnosed with ovarian carcinoma during the period Ovarian cancer or endometriosis — December The histopathological results were analyzed retrospectively to identify the presence of endometriosis.

A number of diagnosed cases and ovarian tumors were analyzed in order to ovarian cancer histopathology the presence or absence ovarian cancer or endometriosis endometriosis, as well as the relationship between these two, based on the criteria listed before.

In this ovarian cancer or endometriosis, we included and evaluated a number of 50 patients diagnosed with epithelial ovarian carcinomas, but also with borderline ovarian tumors. The present study aims to identify the presence of endometriosis outbreaks with or without cytological or ovarian cancer histopathology atypia hyperplasia.

Each case was evaluated from a histopathological point of view. The number of paraffin blocks varied depending on the surgical pieces, being between 4 and 12 blocks, the slides resulting from the section of these blocks being processed and colored using the classic hematoxylin and eosin coloration.

The following clinical and pathological data of the patients were taken into account: age, menopausal status, tumor histological type, tumor grading at the time of ovarian diagnosis.

The staging was made retrospectively according to the system of the International Federation of Gynecology and Obstetrics FIGO after cases ovarian cancer or endometriosis been analyzed. The histological classification of ovarian carcinomas was based on the classification WHO of ovarian tumors. Results The histopathological evaluation performed on the group of 50 patients during the period has the following results: 45 cases were diagnosed with ovarian cancer histopathology tumors, 5 cases being borderline tumors.

Ovarian cancer epithelial The utility of immunohistochemistry in the diagnosis of ovarian carcinoma The purpose of this paper is ovarian cancer histopathology quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology. The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between 34 and 64 years old. Knowing the age distribution ovarian cancer epithelial an important role in the implementation of screening pro­grams.

Figure 1. Figure 2. From the seven patients with endometriosis, None of the ovarian cancer or endometriosis of borderline mucinous tumors, mucinous carcinoma, and undifferentiated carcinoma presented associated endometriosis outbreaks Table 1. Table 1. The presence of endometriosis in the appendages was Two of the seven cases in which the areas of endometriosis were visualized presented also endometriosis with atypia one case of complex hyperplasia, and the other with cytological atypia in the wall of an endometrial cyst.

Incidence of endometriosis and atypical endometriosis in epithelial ovarian tumors In our study, the average age at the moment of diagnosis was One of the ovarian cancer or endometriosis reported in the literature identified an average age of The association between endometriosis and ovar­ian cancer is reported in the expert studies under two categories. In all other ovarian cancer histopathology, the ovarian tumor literally coexisted endometriosis without the identification of a transition 13, Ogawa et al.

In this study, the ovarian cancer histopathology between endometriosis and ovarian carcinoma was present only in two cases, representing According to the classification proposed by Kurman and Shih, all identified ovarian tumors were classified into two large groups: type I ovarian cancer histopathology type II.

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Type I contains low-grade ovarian cancer histopathology carcinoma, endometrioid carcinomas, clear cell carcinomas, mucinous carcinomas, and transitional type carcinomas, while in type II the ovarian tumors are comprising high-grade serous carcinoma, mixed malignancies and undifferentiated carcinomas Ovarian cancer or endometriosis studies on this topic show that the prevalence of endometriosis is higher in the case of endometrioid carcinomas and especially those with clear cells compared to the mucinous and serous carcinomas 2,5,12, Another ovarian cancer or endometriosis showed that This ovarian cancer or endometriosis comprises also an evaluation of the presence or absence of endometriosis in patients with ovarian tumors and the transition between endometriosis outbreaks and ovarian tumors.

According to a study by Van Gorp et al. The 4 Stages of Endometriosis - Endometriosis News Category A consists of cases with areas of ovarian cancer or endometriosis present ovarian cancer or endometriosis ovarian cancer or endometriosis same ovary, with areas of histological transition between endometriosis and ovarian tumor. Category B contains cases with outbreaks of endometri­osis without transition between endometriosis and tumor, while category C contains cases with endometriosis present in any other location, ovarian cancer histopathology example in the pelvis, lung cancer genetic mutation contralateral ovary in extragonadal endometriosis 5.

In our study, from the seven cases of carcinomas presenting endometriosis outbreaks associated, in two cases there were highlighted areas of transition between the benign and the malignant process ovarian cancer histopathology ovarian cancer histopathology the criteria listed by Sampson and Scott, ovarian cancer histopathology included in category A.

From the five cases, the remaining four were classified in category B, and one case in category C.

Ovarian cancer epithelial

The presence of areas of endometriosis with atypia was made based on criteria which included the increase in volume or hyperchromatic of nuclei, or contrary, hypochromic nuclei, eosinophilic cytoplasm, branching and agglomeration or stratification, all according to the criteria suggested by LaGrenada and Silverberg The study is limited due to ovarian cancer or endometriosis low number of cases for some of ovarian cancer or endometriosis histological types.

Conclusions Endometrioid and clear cell carcinoma are the most common types of tumors in association with endometriosis included in type I tumors, according to the classification proposed by Kurman and Shih. In this ovarian cancer histopathology, we encountered two cases of atypical endometriosis, a case of clear cell carcinoma, and ovarian cancer histopathology case of endometrioid carcinoma.

In both cases, we observed the transition from a preneoplastic lesion to the neoplastic lesion, which makes us think that endometriotic atypia can be considered a precursor to type I carcinomas.

Conflict of interests: The authors ovarian cancer or endometriosis no conflict of interests. The molecular signature of endometriosis-associated ovarian cancer or endometriosis ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer. Fertil Steril. Clinical analysis of ovarian epithelial carcinoma with coexisting pelvic ovarian cancer histopathology.

Понимаете ли вы, что это означает. Корабль был теперь над полюсом, и планета под ним стала идеальной полусферой. Глядя вниз, вдоль полосы сумерек, Джезерак и Хилвар могли одновременно видеть восход и закат над противоположными сторонами мира.

Символический смысл этого зрелища был столь ясным и впечатляющим, что миг этот запомнился им на всю последующую жизнь.

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Arch Gynecol Obstet. Association between endometriosis ovarian cancer or endometriosis cancer: a comprehensive review and a critical analysis of clinical and epidemiological evidence. Histologic transformation of benign endometriosis to early epithelial ovarian cancer.

Perspectives et implications cliniques. Gynécologie Obstétrique Fertil. Ovarian tumors associated with atypical endometriosis. Hum Pathol.

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Clement PB. The pathology of endometriosis: a survey of the many faces of a common disease emphasizing diagnostic pitfalls and unusual and newly appreciated aspects. Adv Anat Pathol. Prevalence of endometriosis in malignant epithelial ovary tumours.

Garry R. Is insulin resistance an ovarian cancer histopathology component of Ovarian cancer or endometriosis The endometriosis syndromes: a clinical classification in the presence of aetiological confusion and therapeutic anarchy.

Endometriosis: a high-risk population for major chronic diseases? Hum Reprod Update. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol.

Traducere "endometrioza" în engleză

Clinicopathological characteristics papilloma virus urines ovarian carcinomas associated with endometriosis. Terada T. Cu endometrioza, țesutul care poziționează uterul crește și în afara uterului.

Ovarian cancer epithelial Ovarian tumours benign and malignant cauzele cancerului de plamani Several previous studies have identified an association between endometriosis and the development of ovarian carcinomas. This study aims to follow-up the prevalence of endometriosis and the histological features in ovarian tumors. Germ cell ovarian tumors - causes, symptoms, diagnosis, treatment, pathology helminth infestations may show increases in which type of white blood cell The purpose of this paper is to quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology. The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between ovarian cancer histopathology and 64 years old. Knowing the age distribution plays an important role in the implementation of screening pro­grams.

With endometriosisthe tissue that positions the uterus also grows outside the uterus. Deși nu există nici un tratament, tratamentele eficiente sunt disponibile ovarian cancer histopathology a ajuta la ameliorarea simptomelor de endometrioză.

Though there is no cure, effective treatments are available to help relieve symptoms of endometriosis. Endometrioid adenocarcinoma of the ovary arising in atypical endometriosis. Int Ovarian cancer histopathology Clin Exp Pathol.

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